ROCKing the JAKs
نویسندگان
چکیده
منابع مشابه
ROCKing the JAKs
The endocrine cytokine leptin is mainly secreted by white adipose tissue and plasma leptin levels positively correlate with body fat mass. Via its action on neurons in the hypothalamic arcuate nucleus (ARC), leptin regulates body weight by stimulating energy expenditure and inhibiting food intake. The main signaling pathway of the leptin receptor is the JAK2-STAT3 pathway. A recent publication ...
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References 1 Deming, J.W. (2002) Psychrophiles and polar regions. Curr. Opin. Microbiol. 5, 301–309 2 Deming, J.W. and Eicken, H. (2004) Life in ice. In Planets and Life: The Emerging Science of Astrobiology (Baross, J.A. and Sullivan, W., eds), Cambridge University Press (in press) 3 Bowman, J.P. et al. (1997) Diversity and association of psychrophilic bacteria in antarctic sea ice. Appl. Envi...
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In this issue, Van der Heijde and colleagues report the results of a randomised, prospective, placebo-controlled, dose-ranging trial evaluating the short-term (12 weeks) symptomatic effect of a Janus kinase ( JAK) inhibitor, tofacitinib. This well-conducted and optimally presented trial raised two important points: (1) a potential role of the JAK/signal transducer and activator of transcription...
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ژورنال
عنوان ژورنال: JAK-STAT
سال: 2013
ISSN: 2162-3996
DOI: 10.4161/jkst.24074